FORMULATION AND EVALUATION OF BESIFLOXACIN NON-ERODIBLE OCULAR INSERTS

Objective: Ocular inserts offer many advantages over conventional dosage forms, like increased ocular residence, the possibility of releasing a drug at slow and constant rate, accurate dosing, exclusion preservatives, shelf life. Besifloxacin is very important for treatment infectious conjunctivitis. The present study was aimed to formulate evaluate Non-Erodible Insert using Pullulan polyvinyl pyrrolidone as reservoir, PEG 400 plasticizer, Eudragit RS-100 rate-controlling membrane. Methods: Central composite design employed effect independent variables, i.e., effects amount (X1) PVP (X2) on dependent % moisture absorption In vitro diffusion rate. After evaluation all thirteen batches insert reservoir formulation, BSF2 BSF4 were selected satisfactory formulation sandwiched between membrane, which made up (3 5%). Results: content formulations found be in range 95.33 99.89 %. from (BSF1 BSF13) 62.44 70.62 rate an can benefits such increasing residence time, prolonging release eye 24 h. RS-100, sustained polymer, showed promising released action. Conclusion: concluded that non-erodible successfully developed pyrrolidone, will sustain also reduce frequency administration, thereby may help improve patient compliance.